FDA Approves First Drug That Can Reduce Allergic Reaction After Exposure to Food Allergens

    • The FDA approved the first drug to stop allergic reactions in children and adults after accidentally consuming certain foods.
    • This medication is not intended to treat anaphylaxis or other emergencies.
    • According to experts, this approval could have a significant impact on children and their families.
  • The US Food and Drug Administration has announced that XolairTrustedSource, an injectable drug named TrustedSource, can now be used as a preventative measure after accidental exposure to allergy-triggering foods.
  • The FDA has approved the first drug to reduce the risk of allergic reactions after accidental exposure to multiple foods.
  • Xolair is a generic drug with the name omalizumab that was introduced to the market in 2003. It has previously been approved for treating asthmachronic sinusitishives, and other conditions.

The drug helped 68% of people avoid a serious allergic reaction.

  • In a clinical study with 168 participants, 68% were able, after receiving Xolair, to tolerate 2.5 peanuts of allergen without experiencing a significant reaction.
  • The drug is only approved for those over the age of one.
  • Dr. Dr.
  • Ganjian compares the medication with “a sponge,” which prevents Immunoglobulin E (IgE) from reaching the receptor, causing an allergic response.
  • IgE-mediated foods include fish, milk, tree nuts, and soy. The study that supported this new use of Xolair also tested against cashews and milk.
  • “We don’t have to resign ourselves to having to deal eventually with allergies and be scared for our children when they go to the house of their friends. [Having to] ask, “What’s in that cake?” What are they going eat? So, this is good,” Ganjian said.
  • The medication helps people who have been accidentally exposed to allergens but does not cure food allergies.
  • Xolair does not replace an emergency treatment such as epinephrine.

Who is the best candidate to take Xolair?

  • Dr. Daniel DiGiacomo is an assistant professor of medicine at Hackensack Meridian and works as a pediatrician at K. Hovnanian Children’s Hospital. He says the goals that a family and patient have will determine whether a treatment such as Xolair is right for them.
  • DiGiacomo is a specialist in allergy and immunology. He worked in a center with patients involved in the study in a former job. In his practice, he says, a patient will go through a series of steps before Xolair is considered as a treatment option.
  • There’s also a need for other education and shared decision-making,” DiGiacomo explained.
  • It can involve multiple visits, skin and blood tests, and educating the patient about allergens and emergency treatment options in case of a severe reaction.

Alternatives to reduce food allergies

  • Xolair may not be the only product on the market to help people reduce their allergy risks.
  • Palforzia, or peanut allergen, is available to those aged between 4 and 17. However, it reduces only the risk of a negative reaction to nuts, as opposed to Xolair’s broader application.
  • Ganjian says there are still areas to be explored in order to understand better how Xolair could help patients. These areas will require further research.
  • There is a variety of allergists and programs that desensitize the children, but it can take up to a year,” Ganjian explained. “Allergists may use this along with desensitization protocol to help the child desensitize faster.” We need to investigate this in the future.
  • Also, side effects should always be considered. The FDA warns that this medication comes with anaphylaxis warnings, and those who have “hypersensitivity” should not take it.
  • Ganjian believes that having treatment options that broaden the protection is a positive move forward.
  • When I see children with allergies, it is usually multiple food allergies and multiple triggers. Ganjian stated that he needed something better and more flexible to work with a wider range of foods.


  • FDA approved a drug that can help treat food allergies. The study found that 68% of those taking the drug Xolair could tolerate 2.5 peanuts of allergens without experiencing a severe allergic reaction.


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