The database of proteins, called”the “unknome,” which ranks proteins based on the amount we know about the proteins, has revealed that we have little about the thousands of protein molecules in humans. The team that created the database also demonstrated that some of the proteins listed are necessary for survival.
In order to create the unknome Sean Munro at the MRC Laboratory of Molecular Biology in Cambridge, UK, and his coworkers started with around 20,000 genes for proteins found in humans. They put together closely similar human proteins or genes on the assumption that they may perform similar roles, which resulted in approximately seven hundred protein-protein clusters.
Then, they added closely related proteins in animals that are commonly studied, such as mice and fruit flies, to the clusters since they may serve the same purpose. The researchers then gave each cluster a score based on the amount of entries regarding their members in the primary database of information about the roles of genes, Also called The Gene Ontology Resource.Human proteins that aren’t explicitly studied can still be a top scorer if a similar protein has been studied extensively in a different animal. Proteins are also awarded higher scores when they are considered to be more critical.The database of proteins, called”the “unknome”, which ranks proteins based on the amount we know about the proteins, has revealed that we have little about the thousands of protein molecules in humans. The team that created the database also demonstrated that a portion of the proteins listed are necessary for survival.
In order to create the unknome Sean Munro at the MRC Laboratory of Molecular Biology in Cambridge, UK, and his coworkers started with around 20,000 genes for proteins found in humans. They put together closely similar human proteins or genes on the assumption that they may perform similar roles, which resulted in approximately seven hundred protein-protein clusters.
Then, they added closely related proteins in animals that are commonly studied, such as mice and fruit flies, to the clusters since they may serve the same purpose. The researchers then gave each cluster a score based on the amount of entries regarding their members in the primary database of information about the roles of genes, Also called The Gene Ontology Resource.Human proteins that aren’t specifically studied can still be a top scorer in the event that a similar protein has been studied extensively in a different animal. Proteins are also awarded higher scores when they are considered to be more important.
“We face new challenges, but the general quality is higher,” He agrees. “But we face new challenges.”
In the tasting hall, DW asks Munich-based Lebanese winemaker Marc Hochar of Chateau Musar whether he sees the changing climate as a chance for his business. He’s not sure if he’s in black and white.
“There’s change, there’s no doubt about it,” He declares, “and it’s impacting some more than others, and some are benefitting.” He also points out the rising quality of German red wines as well as English sparkling wine. However, this isn’t all the time.
“If you go to more southern countries, they’re suffering.”
“We face new challenges, but the general quality is higher,” He agrees. “But we face new challenges.”
In the tasting hall, DW asks Munich-based Lebanese winemaker Marc Hochar of Chateau Musar whether he sees the changing climate as a chance for his business. He’s not sure if he’s in black and white.
“There’s change, there’s no doubt about it,” He declares, “and it’s impacting some more than others, and some are benefitting.” He also points out the rising quality of German red wines as well as English sparkling wine. However, this isn’t all the time.
“If you go to more southern countries, they’re suffering.”